Effects of Moderate Level Noise Exposure on Hearing Function in C57BL/6J Mice
SHI Chuang
LIU Ke
YANG Shiming
JIANG Xuejun
SHI Lei
Abstract：Objective To study characteristics of hearing loss in C57BL/6J mice after being exposed to a moderate level noise. Methods Male C57BL/6J mice with normal hearing at age of 5-6 weeks were chosen for this study. The mice were ran-domly selected to be tested immediately after exposure (P0), or 1 day (P1), 3 days (P3), 7 days (P7) or 14 days (P14) after expo-sure. Post-exposure hearing was compared to before exposure. Mice were exposed to a white noise of 100 dB SPL for 2 hrs. ABR thresholds were used to estimate hearing status at each time point. Results Maximal ABR threshold elevations compared to before exposure were seen at P0 at every frequency (P<0.01), more so at high-frequencies (16 kHz and 32 kHz) than lower frequencies (4 kHz and 8 kHz) ( P<0.05 ). From P1 to P14, ABR thresholds were found to decrease progressively, and showed no significant differences from before exposure on P14 (P>0.05). Conclusions There is a frequency specific response to 100 dB SPL white noise exposure in C57BL/6J mice. High-frequency is more susceptible to the exposure. Also, the hearing loss in-duced by this moderate level noise exposure is reversible in C57BL/6J mice.
Keywords：C57BL/6J miceNoise exposureHearing lossTemporary noise-induced hearing lossABR threshold shift
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 307-311 )