The Fate of the Spiral Ganglion Cells After the Cochlear Hair Cells Serious Injuried
WANG Jiangjun
MAO Huajie
DONG LUhua
ZHAI Suoqiang
Mar Long
Abstract：Objective To study morphological changes of spiral ganglion cells (SGN) following severe cochlear hair cells injury. Methods Guinea pigs were given kanamycin sulfate (1000 mg/kg) intramuscularly followed by furosemide (100 mg/kg) intravenously 2 hours later. Auditory brainstem responses (ABRs) and cochlear morphology were examined at 3 days, 7 days, 1 month and 2 months respectively after the treatment. Results ABR thresholds were greatly elevated after the treatment, with no significant difference among the different time groups. Scanning electron microscopy revealed severe damage to cochlear hair cells, especially out hair cells (OHC) after 7 days. There was also extensive loss of inner hair cells in animals with severe auditory function damage while supporting cells in the organ of Corti were preserved. The SGN showed no change on Day 7, al-though severe SGN loss was seen after 1 month, with total collapse of the organ of Corti. Conclusion Drug-induced hearing loss starts with hair cell loss, followed by SGN loss. In addition, the extent of SGN damage seems to correlate to time lapse after drug administration and can take years to develop, which may provide a time window for cochlear implant.
Keywords：kanamycinfurosemidehair cellsspiral ganglion cells
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 593-596 )