Electrophysiological and Pathological Changes in C57BL/6J Mice with Age-Related Hearing Loss
REN Hong-miao
WANG Yi-nan
CHEN Ji-chuan
Abstract：Objective To investigate neuronal apoptosis in primary auditory cortex and changes of auditory acuity in C57BL/6J mice with age-related hearing loss(ARHL). Methods Young (2 months old) and aged (10 months old) C57BL/6J mice were used to detect and compare hearing function changes by auditory brainstem responses. HE staining and Tu-nel-POD methods were used to examine the morphology of primary auditory cortex neurons and compare the apoptotic rates between the two groups. Results Hearing thresholds of the aged group were significantly elevated than the young group. The number of apoptotic neurons in the primary auditory cortex of aged group increased than the young group. Conclusion Apopto-sis of neurons in the primary auditory cortex plays a major role in ARHL in C57BL/6J mice.
Keywords：Age-related hearing loss (ARHL) Presbycusisprimary auditory cortexapoptotic
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 457-460 )