Effects of Lipoic Acid on Abnormal Distortion Product Otoacoustic Emissions Without Hearing Lose Following Blast Noise Exposure
HE Duan-jun
GUO Wang-hong
TANG Jiang-yong
ZHANG Jia-chao
YANG Jin-feng
FU Yan-qiu
Abstract：Objective To investigate the effect of lipoic acid on abnormally low distortion product otoacoustic emissions (DPOAE) with no hearing loss following military noise exposure. Methods Twenty six (41ears) artillerymen,with normal pure tone hearing thresholds and abnormal DPOAEs amplitudes following military noise exposure were randomly divided into 2 groups. The test group with 13 young adults (21 ears) received intravenous drip of lipoic acid (600 mg/day). The control group with 13 young adults (20 ears) received intravenous drip of placebo. Pure tone audiomety and otoacoustic emission were per-formed on Days 2, 4, 6, 8 and 10 after treatment. Pure tone hearing thresholds and amplitudes of DPOAEs were compared and analyzed. Results Statistical analysis showed that prior to the treatment the amplitudes of DPOAE at 3, 4 , 6 and 8 kHz did not differ significantly between the two groups. DPOAE amplitudes in the control group increased significantly on the 8th day after treatment. The amplitudes in the test group increased significantly on the 4th day after treatment, with a significant differ-ence between the test and control groups. Conclusion Lipoic acid seems to significantly improve DPOAE amplitudes toward normal in individuals with subclinical auditory system impairment caused by military noise exposure.
Keywords：Lipoic AcidDistortion Product Otoacoustic EmissionAcute Acoustic TraumaPulse Noise
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 440-443 )