In vivo Dynamic Changes of Endolymph in Guinea Pigs on High-Resolution Magnetic Resonance Hydrography
MENG Ling-zhao
WU Wei
Zeng Ya-wei
Guo Qing
Jin Zhen
HAN Hao-lun
WANG Gang
Sun Jian-zhi
WANG Hong-nan
LI Bao-wei
Abstract：Objectives To investigate whether a clinical 3.0T MRI system can distinguish endolymph from perilymph in vivo in guinea pigs. Methods Five guinea pigs were injected with Gd-DTPA via the internal jugular vein (3 ml/kg) at the mo-ment when inner ear volume scans on a 3.0T MRI system were completed. Susequent inner ear volume scans were taken every 30 minutes for 240 min to detect changes of endolymph and perilymph. Results Only outlines of the cochlea and vestibule were visible before Gd-DTPA injection with no distinction between endolymph and perilymph. Uptake of Gd-DTPA firstly oc-curred in the vestibule and the basal turn, and in the apex of cochlea 30 min after the injection. At 120 min after injection, Gd-DTPA uptake was seen throughout the entire inner ear with clear imaging. Conclusions Endolymph of inner ear can be distinguished from the perilymph on a clinical 3.0T MRI system, which may provide great convenience for the study of endo-lymphatic hydrops.
Keywords：endolymphMRIGd-DTPAguinea pig
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 432-434 )