Strategy of prevention and therapeutics against sensorineural hearing Loss via local application to inner ear
XIA Li
YIN Shan-kai
Abstract：Sensorineural hearing loss is a common disabling disease. The main therapy against this disease in the pres-ent age is that medication is administered via systemic application. However, due to the blood- labyrinth barrier, the concen-tration of drug performs low level when it is administered through systemic application, which causes low therapeutic effect against sensorineural hearing loss. This defect could be averted to large extent via local application, through which the blood-labyrinth barrier is bypassed. In the meantime, along with the developments the technologies of genetic engineering and cytology, local gene transfection and stem cell implantation are applied in the researches of treatments for sensorineural hear-ing loss. This review will examine the mechanism and the potential of therapeutics against sensorineural hearing loss via local application in cochlea.
Keywords：Sensorineural hearing losscochleahearing functiongene transfectionstem cell implantation
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 401-407 )