ABR Changes in a Rat Model of CUMS Induced Depression
CHEN Kang-song
LIAO Hua
YANG Xi-lin
CHEN Jian-xin
Abstract： Objective To study changes of auditory brainstem response (ABR) in a rat model of depression induced by chronic unpredictable mild stress (CUMS). Methods Sixteen rats were randomly divided into a control group (n=8) and a mod-el group (n=8). The model group was randomly treated with CUMS every day to keep animals in a depressive state for 28 days. Animal behaviors were recorded using an automatic tracking system at 1 day before experiment and on Days 14 and 28. In the present study, ABRs were tested using a TDT system on Day 28 for all animals. Results Compared with the control group, the basic indices of animal behavior of the model group were markedly different from the control group on Days 14 and 28 (p<0.01), indicating successful modeling, although there was no statistical difference on ABR thresholds between the two groups (P>0.05). The latencies of waves I and V in the model group were significantly longer than the control group (P<0.05) and the amplitudes of waves II and V were markedly decreased compared to the control group (P<0.05 and P<0.01, respectively). Con-clusion Abnormal neuroelectric activities along the auditory pathway from the peripheral auditory organ to the brainstem may exist in rats with CUMS induced depression .
Keywords：DepressionCUMSAuditory brainstem response
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 284-287 )