Analysis of Mitochondrial DNA 12S rRNA A1555G Mutations in Hearing Im-paired Students from a Deafness School in Guangzhou
Zhou Feng
Lin Ying
Liu Jing
Liang Jian-min
Luo Qiong
Wang Hai-tao
Abstract： Objective To investigate mitochondrial DNA 12S rRNA A1555G mutations in high risk groups with nonsyn-dromic hearing impairment in Guangzhou to provide a theoretical basis for preventing deafness. Methods Clinical data were collected and blood samples taken for genetic testing by PCR-RFLP in 188 hearing impaired students from a deafness school and 100 healthy people. Results Mitochondrial DNA A1555G mutations were not found in either the 188 hearing impaired stu-dents or the 100 healthy people, leading to a frequency of 0,which was significantly lower than the average. Conclusion Guangzhou as a more developed economic region shows a low frequency of mitochondrial DNA 12S rRNA A1555G mutation. Our study provides a molecular basis to predict risk of ototoxicity and to improve the safe use of aminoglycoside antibiotics in potentially high risk groups with nonsyndromic hearing impairment in Guangzhou. The study also serves to, lay a foundation for further research into susceptibility related to deafness genes.
Keywords：Mitochondrial DNAnonsyndromic hearing impairmen-taminoglycoside antibioticsRestriction fragment length polymorphism
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 272-275 )