Effects of Intratympanic Dexamethasone Injection as a Treatment for Autotimmune Hearing Loss
WANG Jing-miao
JIANG Xin-xia
WEI Jun-kuan
MA Jian-gang
Abstract： Objective To investigate the effect of intratympanic dexamethasone injection on autotimmune sensorineu-ral hearing loss which is difficult to treat. Method Intratympanic injection of dexamethasone (3 mg qd for 7 days) was admin-istered in 32 cases of autotimmune sensorineural hearing loss, of which 15 showed no significant hearing improvement after systemic glucocorticoid treatment and 17 showed hearing declination after glucocorticoid taper. If no hearing improvement af-ter 7 days, the treatment was repeated for another 7 days. At 6 months follow-up, hearing and ABR results were recorded and compared to before the injection. Results Average hearing threshold and mean wave V threshold were 64.92±25.36 dB HL and 69.88±18.27 dB nHL, respectively, before intratympanic in the 32 patients, and 46.58±29.32 dB HL and 51.36±20.12 dB nHL respectively after intratympanic injection (P<0.05). Conclusion Intratympanic injection of dexamethasone is a safe and effective adjuvant treatment in the management of autotimmune sensorineural hearing loss.
Keywords：AutoimmueSensorineural hearing lossIntratympanicDexamethasone
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 259-262 )