Interrelation between Advanced Glycation End Products and Adiponectin and Hearing Loss in Type 2 Diabetes Mellitus
XU Huan-huan
LIU Li-zhong
QI Xin-wei
WANG Zhong-xun
Abstract： Objective To study the interrelation between advanced glycation end products ( AGEs) and adiponectin (APN) and hearing loss in patients with type 2 diabetes mellitus (T2DM) . Methods The levels of AGEs and APN were deter-mined by enzyme linked immunosorbent assay ( ELISA) in 49 patients with T2DM and hearing loss (Group A), 55 patients with T2DM and no hearing loss (Group B) and 47 healthy subjects (Group C).Results Body mass index (BMI) and total cho-lesterol (TC) were not significantly different among the three groups (P>0. 05), while fasting glucose (FPG), HbA1c, 2-hour postprandial blood glucose (2hPG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), AGEs and APN levels were significantly different (P<0. 05). Compared with Group C, FPG, HbA1c, 2hPG, LDL- C, TG and AGEs significantly increased but HDL- C and APN significantly decreased in Groups A and B (P<0. 05). AGEs increased and APN decreased in Group A compared with Group B (P<0. 05). In Group A, AGEs were positively correlated with FPG, 2hPG, LDL-C, HbA1c, duration of diabetes and average hearing (P<0. 05) . APN was negative correlated with BMI, FPG, 2hPG, HbA1c , duration of diabetes and average hearing but positively correlated with HDL-C (P<0. 05) . Conclusion AGEs and APN are related with the occurrence and development of hearing loss in T2DM. AGEs and APN may be used as indicators for the early diagnosis and prognosis of the condition.
Keywords：Diabetes mellitushearing lossAdvanced glycation end-productsadiponectin
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 243-246 )