"Clinical Management of Acute Mastoiditis in a Pediatric Patient with Leukocyte Adhesion Deficiency"
Allahverdi Aghayev
Alparslan Gonul
Hazan Basak
Abstract：Leukocyte adhesion deficiency type-1 is frequently associated with otorhinolaryngological manifestations, most notably a high prevalence of otitis media. Although multiple case reports have documented an increased prevalence of acute otitis media and mastoiditis in patients with LAD-1, no clinical or experimental studies have fully elucidated the pathophysiological mechanisms underlying this association. Despite guideline recommendations for urgent antibiotic therapy in immunocompromised patients with acute otitis media, a standardized treatment protocol for its complications remains lacking. Moreover, no established consensus exists regarding the optimal therapeutic approach for Leukocyte adhesion deficiency type-1 associated cases. This report contributes to the scarce literature on acute mastoiditis in LAD-1 and underscores the need for a tailored, multidisciplinary approach. In the absence of standardized treatment protocols, further research is crucial to refine management strategies and improve outcomes in immunocompromised patients with acute otitis media complications.
Keywords：Leukocyte Adhesion DefectImmunodeficiencyAcute MastoiditisMastoidectomy
Publication Date：2025-04-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 127-132 )