Research Progress on the Regulation of Neutrophil Extracellular Traps in the Pathogenesis of Gouty Arthritis and Its Prevention and Treatment with Traditional Chinese Medicine
LI Yonghong
YANG Juanjuan
LI Haolin
JING Luoyang
LU Dongsheng
GAO Yanhua
YANG Huijun
WANG Haidong
Abstract：Gouty arthritis(GA)is an immune inflammatory disease caused by the deposition of monosodium urate(MSU)crystals.Its incidence is increasing year by year and is trending younger,becoming a prominent global health issue.Neutrophil extracellular traps(NETs)play a crucial role in the pathological process of GA.The formation and regulation mechanisms of NETs are complex,involving multiple signaling pathways and cellular processes.Traditional Chinese medicine(TCM)has the characteristics of multiple pathways and multiple targets in the treatment of GA.On one hand,it can inhibit the formation and release of NETs,thereby alleviating the inflammatory response.On the other hand,it exerts regulatory effects on NETs by modulating relevant signaling pathways and cellular processes.This article summarizes,analyzes,and organizes the mechanism of NETs in GA,and discusses the research progress of TCM in regulating NETs to treat GA in recent years,with the aim of providing theoretical support for the research on TCM treatment of GA.
Keywords：Gouty arthritisNeutrophil extracellular trapsPathogenesis
Publication Date：2026-03-28
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：7( 711-716,后插1 )