Research Progress on Da Chengqi Tang in Improving Mental Disorders in Yangming Disease Based on the Microbiota-Gut-Brain Axis
HE Xin
TAN Yingying
Abstract：The chapter on Yangming disease in the Treatise on Cold Damage Diseases frequently mentions manifestations of mental disorders and provides unique insights into their treatment.The primary therapeutic approach often involves Da Chengqi Tang,a representative formula for syndrome of Yangming and Fu-organ excess.Notably,syndrome of Yangming and Fu-organ excess is often accompanied by significant disruption of the gut microbiota.The microbiota-gut-brain axis(MGBA)is a current research hotspot,as gut microbiota can influence many neurological diseases through this axis.Recent studies have indicated that traditional Chinese medicine can regulate gut microbiota and their metabolites,exerting neuroprotective effects,though the underlying mechanisms require further exploration.Based on the MGBA theory,this article reviews the mechanisms by which Da Chengqi Tang improves mental symptoms by modulating gut microbiota and their key metabolites,short-chain fatty acids(SCFAs),providing new insights for the treatment of mental disorders with traditional Chinese medicine.
Keywords：Microbiota-gut-brain axisDa Chengqi TangYangming diseaseMental disordersShort-chain fatty acids
Publication Date：2026-03-28
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：5( 687-691 )