Analysis of Medication Patterns and Potential New Formulations for Chest Pain and Heartache(Coronary Heart Disease)with Blood Stasis Syndrome Based on the Correlation of"Medicinal-Syndrome-Dosage"

DU Li; ZHAO Bonian

doi:10.3969/j.issn.1006-3250.2026.03.038

Abstract：Objective To explore the compatibility patterns of traditional Chinese medicine(TCM)in treating chest pain and heartache(coronary heart disease)with blood stasis syndrome through data mining,providing a basis for clinical application and new drug development.Methods TCM prescriptions were collected and organized from the Dictionary of Traditional Chinese Medicine Formulas and the preparation section of the Pharmacopoeia of the People's Republic of China(2020 edition).Screening criteria were set to include effective TCM prescriptions,which were then standardized.Frequency statistics,cluster analysis,complex network analysis,and association rule algorithms were applied to analyze the core medications and formulation patterns for chest pain and heartache(coronary heart disease)with blood stasis syndrome.The Gephi ForceAtlas algorithm was used for the visual presentation of association analysis results.Results A total of 125 prescriptions for chest pain and heartache(coronary heart disease)with blood stasis syndrome were screened,involving 226 TCM medicinals with a total frequency of 846 occurrences.The medicinal properties were predominantly warm,with flavors mainly pungent,bitter,and sweet.The medicinals primarily targeted the spleen,liver,and heart meridians,with their main effects focusing on promoting blood circulation and removing stasis,tonifying deficiency,and regulating Qi.Cluster analysis yielded two new formulations,and eight core medicinals were identified,along with one core medicinal prescription.Modular analysis clearly demonstrated the association and compatibility relationships of high-frequency medicinals across various subtypes of blood stasis syndrome.The average dosage ratio of Danggui(Angelicae Sinensis Radix)to Danshen(Salviae Miltiorrhizae Radix et Rhizoma)was approximately 2·1 when used for Qi stagnation and blood stasis syndrome or heart blood stasis obstruction syndrome.Conclusion Chest pain and heartache(coronary heart disease)with blood stasis syndrome is characterized by a deficiency in the root and excess in the manifestation,with compatibility emphasizing medicinals that promote blood circulation and remove stasis,tonify deficiency,and regulate Qi.The combination of Danggui and Danshen is the primary compatibility pair for preventing and treating chest pain and heartache(coronary heart disease)with blood stasis syndrome,with clinical recommendations for doubling the dosage of Danggui.This study provides new insights for the prevention and treatment of chest pain and heartache(coronary heart disease),as well as for the compatibility and dosage of new formulations.