Research Progress on Traditional Chinese Medicine Targeting Mitochondrial Quality Control for Preventing and Treating Atherosclerosis
YANG Liping
WANG Qian
GONG Yushuan
XIANG Lei
YANG Zhaodi
WEI Huiping
Abstract：Atherosclerosis(AS)is a chronic vascular inflammatory disease characterized by persistent inflammatory responses,activation of inflammatory vesicles,and cellular inflammatory damage.The pathogenesis of AS is complex,and emerging evidence in recent years highlights the critical role of mitochondrial dysfunction in its development.Traditional Chinese medicine(TCM),with its advantages of multi-target and multi-pathway interventions,has garnered widespread attention for regulating mitochondrial homeostasis and preventing and treating AS.TCM can exert its preventive and therapeutic effects on AS by targeting the regulation of mitochondrial oxidative stress,dynamics,autophagy,biosynthesis,apoptosis,and calcium homeostasis.Based on this,this article reviews the relationship between mitochondrial quality control systems and atherosclerosis,as well as the mechanisms of TCM interventions targeting mitochondrial quality control systems for the prevention and treatment of AS.The aim is to provide new insights for TCM in preventing and treating AS and to offer a theoretical basis for clinical research on TCM interventions for AS.
Keywords：Mitochondrial quality controlAutophagyApoptosisAtherosclerosis
Publication Date：2026-02-28
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：7( 449-455 )