Understanding the Pathogenesis of Ulcerative Colitis Recurrence Based on the Latent Pathogen Theory
WANG Xintong
ZHANG Jiaqi
TANG Xudong
Abstract：Latent pathogens,as pathogenic factors that remain hidden in the body after infection and cause delayed onset,are the core cause of recurrent ulcerative colitis(UC).The characteristics of latency,progression,and accumulation of latent pathogens align with the pathogenesis of UC,which is"deficiency of vital Qi as the root,and damp-heat and blood stasis as the manifestation".This perspective also correlates with pathological mechanisms confirmed by modern medicine,such as mucosal barrier damage and persistent activation of tissue-resident memory cells.Based on the latent pathogen theory,this paper explores the evolutionary patterns of UC recurrence and corresponding treatment principles.It also proposes the"new eight principles of syndrome differentiation for spleen and stomach diseases"as a guideline for syndrome differentiation and treatment during remission,offering new insights into the prevention and treatment of UC recurrence with traditional Chinese medicine.
Keywords：Ulcerative colitisLatent pathogensRecurrenceTissue-resident memory T cells
Publication Date：2026-02-28
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：5( 329-333 )