Mechanism Analysis of Treating Hyperlipidemia Based on the"Spleen-Stale Qi-Vessel Accumulation"Pathogenesis Theory and the"Interaction of Water and Stasis"Theory
HE Yuwei
GUAN Shujun
LIU Di
WU Wenlong
LI Ting
ZHANG Yan
ZHAO Xin
Abstract：The theory of"stale Qi"can be traced back to Inner Canon of Huangdi.It refers both to the pathological products formed from the accumulation of rich and sweet foods due to improper diet,and to various pathological substances generated during the body's metabolic processes.Hyperlipidemia,as a core pathological link in the spectrum of metabolic diseases,also serves as a prerequisite and foundation for the progression of many metabolic diseases to atherosclerosis.Modern medical research indicates that abnormal lipid metabolism shares high consistency in pathological characteristics with the traditional Chinese medicine(TCM)theory of"stale Qi".Based on classical TCM theories,this study innovatively proposes the pathogenesis perspective of"Spleen-Stale Qi-Vessel Accumulation".Spleen dysfunction in transportation and transformation is the initiating factor in the onset of the disease.Stale Qi acts as a key intermediate pathological product formed during the middle stage due to spleen dysfunction and internal phlegm-turbidity.With the persistent accumulation and dispersion of stale Qi,the transportation and transformation of Qi,blood,and body fluids become impaired in the later stage,ultimately leading to damage of the vessels and collaterals,where water and stasis interact and accumulate within the vessels,resulting in the pattern of vessel accumulation.Therapeutically,by applying the theory of"Interaction of Water and Stasis",this study elaborates on the theoretical connotation of hyperlipidemia in TCM and its modern medical extensions,aiming to provide new ideas and methods for the prevention and treatment of this disease with TCM.
Keywords：HyperlipidemiaSpleen dysfunction in transportation and transformationStale QiVessel accumulationInteraction of water and stasis
Publication Date：2025-11-28
Online Publishing Date：2025-12-01(First online date of this platform, not the publication date of the document)
Pages：5( 1903-1907 )