Research of the Traditional Chinese Medicine Syndrome Distribution and Clinical Characteristics of Cardio-Oncology

LIN Hongyuan; WEI Xiaohong; PENG Mengqi; DENG Xiangqin; ZHANG Xiaowei; KONG Yifan; SHANG Hongcai

Abstract：Objective To explore the clinical characteristics and distribution of traditional Chinese medicine(TCM)syndromes in patients with cardio-oncology,in order to provide basis for the prevention and treatment of cardio-oncology.Methods In this study,117 cases of cancer therapy-related cardiac dysfunction(CTRCD)in Dongzhimen Hospital,Beijing University of Chinese Medicine were retrospectively collected.This study involved the descriptive analysis of demographic characteristics,clinical symptoms,tongue and pulse features,and syndrome elements.The clinical data of patients who met the measurements and the distribution of TCM syndrome elements.Results There were 51 cases of symptomatic CTRCD(43.59%)and 66 cases of asymptomatic CTRCD(56.41%)among the 117 patients,and all of them were predominantly mild to moderate.Seven markers of myocardial injury,including b-type natriuretic peptide(BNP),were significantly elevated in the symptomatic CTRCD group compared with the asymptomatic CTRCD group(P<0.01).After normalising the information of the four diagnostic examinations of CTRCD patients,a total of 32 kinds of symptom information,9 kinds of tongue information and 6 kinds of pulse information were included.The syndrome elements as a whole were classified into three categories,namely,single syndrome elements,double syndrome elements and multiple syndrome elements,of which 92 cases(78.63%)of double syndrome elements accounted for the highest percentage.Based on the combination pattern of the different syndrome elements,a total of five major TCM syndrome elements were obtained.They were Qi-Yin deficiency syndrome,Qi-blood deficiency syndrome,Qi-Yang deficiency syndrome,Qi deficiency and blood stasis syndrome,and phlegm and stasis syndrome,among which Qi-Yin deficiency syndrome accounted for the highest proportion(26.5%).Compared with patients in the asymptomatic CTRCD group,the difference in the distribution of Qi and Yin deficiency syndrome in the symptomatic CTRCD group was not statistically significant,and Qi-Yang deficiency syndrome were predominantly distributed in the group of symptomatic CTRCD(P<0.05).Conclusion The vast majority of patients in cardio-oncology are classified as mild to moderate,and clinical prevention and treatment may need to shift the focus forward.The most common TCM syndrome type is Qi-Yin deficiency syndrome,which runs through the progression of cardio-oncology from mild to severe.