Clinical Efficacy Evaluation of Baofei Kang in the Treatment of Chronic Obstructive Pulmonary Disease with Pulmonary Interstitial Fibrosis

CHEN Qiuyi; GUO Yujie; CUI Hongsheng; JIN Ruifeng; BI Weibo; LYU Mingsheng

Abstract：Objective To observe the clinical efficacy of Baofei Kang in treating patients with chronic obstructive pulmonary disease with pulmonary interstitial fibrosis(COPD-PIF)of Qi Yin deficiency and phlegm stasis obstruction syndrome.Methods The COPD-PIF patients who met the inclusion criteria were divided into two groups according to the random number table method,and the treatment group was given the combination of traditional Chinese medicine Baofei Kang and Western medicine treatment,while the control group was given the combination of traditional Chinese medicine placebo and Western medicine treatment,and the treatment course was 3 months.Observe and compare the treatment efficacy rates,as well as the changes of TCM syndrome scores,lung function,partial pressure of oxygen in arterial blood(PaO2),COPD assessment test(CAT)score,modified British medical research council(mMRC)score,and the times of exacerbation in the two groups before and after treatment.Results The treatment group showed improvement(P<0.05)in total score of TCM syndrome,main symptom score,forced expiratory volume in one second(FEV1)%pred,PaO2,CAT score,mMRC score,and times of acute exacerbation,while the curative efficacy was better than that of the control group.Correlation analysis showed that the improvement of TCM syndrome score was significantly positively correlated with CAT score,mMRC score and significantly negatively correlated with FEV1%pred and diffusing capacity of the lung for carbon monoxide(DLCO)%pred.Conclusion Baofei Kang can effectively improve the symptoms of COPD-PIF patients such as wheezing,chest tightness,shortness of breath,cough,expectoration,and fatigue,reduce the CAT score,mMRC score,improve PaO2,improve the patients'pulmonary function,reduce the times of acute exacerbation.It has significant clinical efficacy,and do not show any adverse effects,which deserves to be promoted.