Clinical Observation on the Therapeutic Effect of Qizhu Feixian Decoction on Idiopathic Pulmonary Interstitial Fibrosis
ZHANG Wenjing
YIN Jiankun
LI Meng
LI Hui
LI Guangxi
WANG Qiuming
GAO Yang
LIU Shigang
LI Guoqin
Abstract：Objective To explore the clinical effect of Qizhu Feixian decoction on idiopathic pulmonary fibrosis(IPF)patients.Methods A total of 40 IPF patients admitted to Guang'anmen Hospital,China Academy of Chinese Medical Sciences from October 1st,2019 to December 31st,2021 were included,and divided into trial group and control group at random,with 20 cases in each group.The control group was given acetylcysteine capsules plus Bailing capsules,and the trial group was given Qizhu Feixian decoction in addition.After 3 months of treatment,the pulmonary function,6-minute walk distance(6MWD),resting oxygen saturation(SpO2),the sores of the Saint George's respiratory questionnaire(SGRQ),serum krebs von den lungen(KL)-6 level,and the semi-quantitative scores of high-resolution ct(HRCT)were observed in both groups.Results After treatment,the carbon monoxide diffusing capacity/predict value(DLCO%)in the trial group was obviously higher than that in the control group(P<0.01).After treatment,the total scores of SGRQ,the scores of symptom,the scores of influence of disease,the level of KL-6,and the scores of HRCT in the trial group were lower than those in the control group(P<0.05).There was a positive correlation between lung function grade and HRCT semi-quantitative scores(r=0.849,P<0.01).Conclusion Qizhu Feixian decoction can delay the progression of pulmonary fibrosis in patients with IPF.It is worthy of further promotion.
Keywords：Qizhu Feixian decoctionIdiopathic pulmonary fibrosisLung functionSGRQKL-6HRCT
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 479-483 )