Research Progress on Intestinal Immunity in Ulcerative Colitis
LI Yang
SONG Zhiqian
LU Xinyue
WANG Chun
PENG Shitao
ZHANG Ting
NING Zhangchi
Abstract：Ulcerative colitis(UC)is a chronic nonspecific disease of the colon and rectum whose etiology is not well defined.UC is closely related to intestinal immunity.Intestinal-associated lymphoid tissue and lamina propria contain abundant immune cells,which play an important role in maintaining intestinal immune homeostasis.The imbalance of T helper cell(Th)17/T regulatory cell(Treg)was proved to be relative to intestinal immune homeostasis of UC,which was affected by metabolic reprogramming of cells.To provide a reference for UC research,this paper mainly reviewed the studies from three aspects:enteric-associated lymphoid tissue and various immune factors in lamina propria related to UC,metabolic reprogramming of Th17/Treg cells,and traditional Chinese medicine immune regulation treatment of UC.
Keywords：Ulcerative colitisIntestinal immunityT helper cellT regulatory cellsMetabolic reprogramming
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 168-175 )