Theoretical Connotation and Clinical Application of"Enlightening the Spirit by Modulating Pivot"Innovative Theory in the Treatment of Depressive Comorbidity
LI Shaoyuan
ZOU Ningyi
XIN Chen
LIU Bing
ZHANG Yuzhengheng
WANG Yu
WANG Yifei
RONG Peijing
Abstract：Depression is a systemic disease that poses a serious threat to human health,often occurring in conjunction with pain,insomnia,functional gastrointestinal disorders,diabetes mellitus,etc.These depressive co-morbidities have a high morbidity rate,complex mechanisms,a high burden of disease,and limited therapeutic means.At this stage,clinical practice and scientific research are mostly conducted around a single disease or system,and the single-disease oriented clinical diagnosis and treatment model is in need of a breakthrough.In this paper,we originally proposed the innovative doctrine combining Chinese and Western medicines in the treatment of depressive co-morbidities by"enlightening the spirit by modulating pivot",formed the innovative treatment method of transcutaneous auricular vagus nerve stimulation that treats different diseases with the same method,and obtained the neurobiological basis and evidence-based medical evidence for the treatment of pain/depression,insomnia/depression,functional gastrointestinal disease/depression,and diabetes/depression co-morbidities.It would provide a new idea and method for clinical treatment.
Keywords：Enlightening the spirit by modulating pivotDepressionComplicationsMechanismsClinical applications
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 95-99 )