Experimental Research Progress of Traditional Chinese Medicine Treatment of Non-Alcoholic Fatty Liver Disease Based on PPAR-related Pathway
HUANG Chaoyuan
ZHAO Zhimin
LI Wei
CHENG Yimin
ZHENG Yiyuan
LIU Fengbin
Abstract：Peroxisome proliferator-activated receptor(PPAR)is a kind of transcription factor that is involved in sugar and lipid metabolism,inflammatory response and cell proliferation,differentiation,and apoptosis.In recent years,an increasing number of studies have been conducted on the related pathways of the three subtypes of PPAR,and it has been found that PPAR played an important role in the transformation process of non-alcoholic fatty liver disease.From monomer and compound Chinese medicine to patent Chinese medicine and external treatment of traditional Chinese medicine(TCM),all of which showed that TCM intervention had a good clinical effect on the treatment of non-alcoholic fatty liver disease(NAFLD).The number of fundamental experiment studies to elucidate the mechanism of TCM in the prevention and treatment of NAFLD based on PPAR pathways is increasing.This article will review the experimental studies on the mechanism of TCM prevention and treatment of NAFLD in recent years from the perspective of PPAR pathways.
Keywords：Peroxisome proliferator-activated receptorNon-alcoholic fatty liver diseaseResearch progress
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2112-2116 )