Study on the Characteristics of Face,Tongue,and Pulse in Non-Small Cell Lung Cancer

GUO Dandan; LOU Jindi; SHI Yulin; TU Liping; XU Ling; YANG Yun; XU Jiatuo

Abstract：Objective Taking patients with non-small cell lung cancer(NSCLC)and patients with tiny pulmonary nodules as research subjects,we studied the facial,tongue,and pulse characteristics of NSCLC and their correlation with tumor markers.Then explore the role of facial,tongue,and pulse data in the diagnosis of NSCLC.Methods We collected 377 patients with NSCLC and 368 patients with tiny pulmonary nodules,then analyzed and extracted their facial,tongue,and pulse data.We used Wilcoxon rank-sum test to analyze the difference in facial,tongue,and pulse data between the two groups.We used the Spearman's rank correlation coefficient to represent the correlation between facial,tongue,pulse data and tumor markers.Results The tongue image parameters Per-all,TC-L,TB-CON,TB-ENT,TB-MEAN,and TB-L in the NSCLC group were lower than those in the tiny pulmonary nodules(P<0.05),while TC-a,TC-b,TB-ASM,TB-a,and TB-b were higher than those in the tiny pulmonary nodules group(P<0.05).The facial tongue image parameters F-ASM,F-IDM,and F-L in the NSCLC group were lower than those in the tiny pulmonary nodules group(P<0.05),while F-CON,F-ENT,F-a,and F-b were higher than those in the tiny pulmonary nodules group(P<0.05).The pulsogram parameters h4/h1,h5 and t in the NSCLC group were smaller than those in the tiny pulmonary nodules group(P<0.05);h3/h1,h1/t1,t1/t,t4/t5,w1/t,w2/t,h1,h3,h4,t4 were higher than those in the tiny pulmonary nodules group(P<0.05).All the serum tumor markers included in the study were correlated with facial,tongue,and pulse data.Conclusion There were significant differences in facial,tongue and pulse characteristics between NSCLC patients and patients with tiny pulmonary nodules.And there was a correlation between facial,tongue,pulse parameters and various tumor markers.So we can use facial,tongue,pulse data to assist in the diagnosis of benign and malignant pulmonary nodules in clinical practice.