Effects of Yiqi Yangyin Guchong Recipe and Its Disassembled Prescriptions on MMP-9 and TIMP-1 in Endometrium of Rats with Anovulatory Dysfunctional Uterine Bleeding with Both Deficiency of Qi and Yin Syndrome
BAO Hong-tao
WANG Ting
WU Quan-sheng
Abstract：Objective: To study and analyze the effect of Yiqi Yangyin Guchong prescription and its disassembled prescriptions on theuterus matrix metalloproteinases 9 and Tissue inhibitor of metalloproteinase-1 of anovulatory dysfunctional uterine bleeding model rats with Qi-Yin deficiency syndrome. Methods: Seventy female SD rats were randomly divided into blank control group, model control group, Gongxuening group, Yiqi group, Guchong group, Yangyin group and all the groups.each group were treated with the corresponding drugs and saline, expression of endometrium MMP-9 and TIMP-1 in endometrium. Results: The model control group MMP-9 activity decreased, TIMP-1 activity increased, the control group were statistically significant compared with the blank; The activity of MMP-9 was increased in the drug delivery group and the activity of TIMP-1 was decreased, the control group were statistically significant compared with the model. Conclusion:The treatment group of endometrial MMP-9 expression increased, TIMP-1 expression decreased in whole group and Yiqi group changed more obviously, so the method can promote endometrial repair to achieve the treatment of anovulatory dysfunctional uterine bleeding.
Keywords：Anovulatory dysfunctional uterine bleedingQi-Yin deficiency syndromeYiqi Yangyin Guchong prescriptionMatrix metalloproteinase-9Tissue inhibitor of metalloproteinase-1
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 927-930 )