Effect of Spleen Deficiency On The Level of Lipid Mediators In Asthmatic Rats and The Intervention Effect of Chiropractic Method
XIONG Ying
FAN Pu
SHEN Chu-chu
ZHOU Rui-peng
CHEN Xiao
Abstract：Objective: To observe the influence of spleen deficiency on the level of lipid mediators in asthma rats and the intervention effect of spine-pinching manipulation. Methods: 44 SD rats were divided randomly into normal control group (group C), asthma group (group A), asthma with spleen deficiency group (group AS) and spine-pinching manipulation on asthma with spleen deficiency group (group SAS). The asthma model was established based on the spleen-deficiency model. Spine-pinching manipulation was applied to intervene the spleen deficency. HE staining and ELISA were used to detect the pathology of lung tissues and the level of lipid mediators in bronchoalveolar lavage fluid (BALF). Results:Comparing to group A, the pathological change of lung tissues in group AS was more severe and the ratio of LXA4/CysLTs and PGE2 level were significantly lower and higher respectively. Comparing to group AS, the pathological change of lung tissues in group SAS was milder, and the ratio of LXA4/CysLTs and PGE2 level were significantly higher and lower respectively. Conclusion: Spine-pinching manipulation could improve the inflammation resolution of asthma with spleen deficiency, which may be one of the mechanism of spine-pinching manipulation on the prevention and treatment of children asthma.
Keywords：Spleen defrcrencyAsthmaSpine-pinehingCipid mediators
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 916-919 )