Effect of Linggui Zhugan Decoction on Doxorubicin Induced Heart Failure in Rats and Its Mechanism
ZOU Ya-xing
WU Wen-yu
LUO Li
LONG Feng-xi
GUO Bin
CHEN Jie
WANG Qian
CHEN Zhi-ping
Abstract：Objetcs: To observe the improving effect of Linggui Zhugan Decotion on heart failure induced by doxorubicin in rats and its effects on myocardial energy metaboliam. Methods: This research used doxorubicin by intraperitoneal injection to make heart failure rats model (2. 5 mg/Kg per time, 6 times in 2 weeks, total 15 mg/Kg), then aqueous solution of Linggui Zhugan Decotion (0. 2 g/m L) were administered to them for 2 weeks. Results: Linggui Zhugan Decotion can significantly improve the cardiac function and hemodynamics. It reduces the HW/BW ratio and free fatty acids, inhibits AMPK phosphorylation, and increases ATP content. Conclusion: Linggui Zhugan Decotion can improve the cardiac function of heart failure rats induced by doxorubicin. The mechanism may be through the inhibition of AMPK activation and fatty acid oxidation.
Keywords：Myocardial energy metaboliamDoxorubicinHeart failureAnimal experimantTraditional Chinese herbs
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 912-915,954 )