Effect of External Application of Duzheng Jiegu Paste on the Expression of BMPR-1A and BMPR-1B mRNA During Fracture Healing in Rabbits
HUANG Qiong
XIANG Yang
Abstract：Objective:To investigate the effect of expression of BMPR-1 B mRNA and BMPR-1 A in the healing process of Duzheng Jiegu Paste on rabbit fracture,and to analyze the mechanism of promoting fracture healing.Methods:30 rabbits were randomly divided into experimental group and control group,with 15 rabbits in each group.The experimental group in the affected area with Duzheng Jiegu Paste and small splint fixation,The control group without of drugs,only after routine disinfection of small splint fixation.On 3rd and 6,10 weeks after the treatment,respectively,each group of 5 randomly selected,x-ray observation of fracture healing.Death affected area from the tumor specimens of rabbits,rabbit bone tissue was determined by real-time fluorescent quantitative PCR method in the BMPR-1A and BMPR-1B mRNA content,statistical analysis of the data.Results:Real time fluorescent quantitative PCR showed that the expression of rabbits of BMPR-1A and BMPR-1B mRNA were higher than those in the control group in the experimental group third and tenth weeks,the affected area of bone tissue specimens,the difference was statistically significant.Conclusion:Duzheng Jiegu Paste can also promote fracture healing in the early expression of BMPR-1A and BMPR-1BmRNA in bone tissue,it can maintain the expression of late,slow attenuation trend,promote fracture healing.
Keywords：Duzhenggan Jiegu PasteFractureHealRabbits
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1391-1393,1409 )