Study on the Effect and Mechanism of Potentilla Discolor on Ulcerative Colitis in Rats
PEI Ling-yan
ZHANG Chun-fang
LIU Wei-zhi
KE Yu-shi
WANG Lin
Abstract：Objects:To study the pesticide effectiveness of Potentilla discolor Bunge on treating ulcerative colitis(UC) rats,and to explore the molecular mechanism of Potentilla discolor Bunge in the treatment of UC.Methods:The UC rats were induced by trinitrobenzene sulfonic acid-ethanol enema.The rats were divided into six groups:blank control group,model control group,sulfasalazine group,low potentilla discolor,Middle and high dose groups.After 14 consecutive days,chloral hydrate was used to make the rats narcotized and colonic tissue was embedded in paraffin,serially cut and stained for microscopic observation.TLR4 and NF-κBP65 in the remaining colon tissue were detected by western blot.Results:Compared with the blank control group,the DAI index and pathological morphologic change in the model group were significantly different.The therapeutic effect in low-dose group was the best.Compared with the blank control group,the expression of NF-κBP65 was significantly increased in the model group.All the Potentilla discolor Bunge groups could down regulate the NF-κBP65 expression level.Conclusion:Potentilla discolor Bunge could exert its effect on UC by regulating the expression level of NF-κBP65 in UC rats.
Keywords：Potentilla discolor BungeUCPharmacological functionTLR4NF-κBP65
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1238-1240,1297 )