Effect of Hu Mai Powder on the Expression of E-selectin and ICAM-1 in Vascular Endothelial Cells of Mice with Phlebitis

QIU Min; Liu Li; ZOU Wen-juan; SUN Ke

Abstract：Objective:to study the effects of HuMai powder on expression of E-selectin and ICAM-1 in mouse vascular endothelial cells with infusion phlebitis.Methods:The phlebitis model of mice was established by injection of vinorelbine via tail vein.Different dose HuMai powder were used as two methods of prevention and treatment,compared by mucopolysaccharide polysulfate cream as a control drug,the degree of tail swelling was as effectiveness index in different mice groups.E-selectin,P-selectin,ICAM-1,VCAM-1 were also as observation index in mouse vascular endothelial cells.Results Different dose HuMai powder can effectively alleviate the inflammatory swelling of the tail of mice induced by vinorelbine,the effect was dose dependent.As compared with the blank group,Vinorelbine can increase the expression of E-selectin and ICAM1 in mouse vascular endothelial cells in the model group.No positive expression of P-selectin and VCAM-1 were found in mouse vascular endothelial cells before and after drug administration.The expression levels of Eselectin and ICAM-1 in mouse vascular endothelial cells were significantly lower in high dose prevention group and treatment group than that of model group.Conclusion:The positive expression of E-selectin and ICAM-1 in vascular endothelial cells were involved in the occurrence of chemotherapy infusion phlebitis induced by Vinorelbine.HuMai powder could inhibit the expression of E-selectin and ICAM-1 in vascular endothelial cells caused by vinorelbine,thus effectively prevent and cure infusion phlebitis.