Experimental Study on Synaptic Plasticity in Rats with Kidney Deficiency Based on SNAP-25 expression
SUN Li-jun
SUN Yao-guang
SUN Yu-ru
ZHANG Qi
LIU Xi-ru
BAI Yun-fei
Abstract：Object:Through the experimental study about expression of hippocampal synapse associatec protein-25 of rats with kidney-deficiency constitution,to discuss the molecular biology mechanism of decreased synaptic plasticity due to kidney-deficiency constitution.Method:Used the way of "cat scare rat" to scare pregnat rats.After they gave birth to a child,their offsprings got on being scared to built composite ratesl with deficiency and acquired dystrophy.Then kidney reinforcing drugs gave treatment for 3 months,Morris water maze tested offsprings' study and learning capacity and immunohistochemical method tested their expression of SNAP-25.Results:Morris water maze test:The incubation period,total distance and the first time through target area of model group were longer than blank group,while in ZuoGui pill and YouGui pill groups,these indexes were better than model group;The change of neurotransmitter NE content:Compared with the blank group,the NE content in model group was reduced.Compared with the model group,the NE content in ZuoGui pill and YouGui pill group was increased;Expression of SNAP-25:The expression in model group decreased than blank group;but compared with model group,it increased when kidney reinforcing drugs was given.Conclusion:The decreased synaptic plasticity is related with the expression of SNAP-25,and it can be improved by the kidney reinforcing drugs.
Keywords：Kidney-deficiency constitutionSNAP-25Synaptic plasticity
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1217-1219,1279 )