Establishment of the "Qi and Yin Deficiency" Model in the Diabetic Macrovascular Diseases
LI Hai-yang
QIN Hai-zhi
CHAO Jun
FANG Chuan-ming
FU Xiao-xu
GAO Hong
XIE Chun-guang
Abstract：Objective:To establish models of Qi and Yin deficiency state and syndrome in diabetes mellitus macroangiopathy.Methods:20 Wistar rats were included in the control group,while 60 male GK rats (random blood glucose ＞ 11.1 mmol/L)were randomly divided into GK group,model group and Chinese traditional medicine (TCM)group,20 rats in each group.Control group and GK group feed ordinary,model group and TCM group eat with high fat feed.TCM group had a Chinese medicine treatment at the same time.After 5 weeks,testing fasting blood ghcose、fasting serum insulin (FINS),insulin resistance index (HOMA IR),Total cholesterol;triglycerides and vascular endothelial cell apoptosis;caspase-3 express;Light microscope observe pathology of the Abdominal aorta.Results:compared with the control group and GK group,the blood glucose,TC,TG,insulin resistance,vascular endothelial cell apoptosis,and large blood vessels tissue pathological have significant differences.Compared with the control group,TCM group all the indexes have improved significantly.Conclusion:By feeding the GK rats with high-fat feed,models of Qi and Yin deficiency state and syndrome in type 2 diabetes mellitus macroangiopathy was successfully established.
Keywords：Diabetes mellitus macroangiopathyQi and Yin deficiencyAnimal models
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 325-328 )