Effect of Intestinal Absorption Solution of Angelica Pubescens on the Tension of Rat Thoracic Aortic
HUANG ying
WU hong-wei
WANG yan-ping
Abstract：Objective:To observe the vasodilatation effect of intestinal absorption solution of Angelica Pubescens on thoracic aorta and its related mechanism.Methods:Intestinal absorption solution of Angelica Pubescens was prepared by everted gut sac method in vitro.To investigate the influence and the calcium-related mechanisms of intestinal absorption solution of Angelica Pubescens on endothelium intact or endothelium denuded with PE and KC1.Results:Intestinal absorption solution of Angelica Pubescens could produce relaxation of thoracic aortic rings pre-contracted by PE and KCl with endothelium intact or denuded in a dose dependent manner.There was no significant difference between the endothelium intact group and the endothelium denuded group.Intestinal absorption solution of Angelica Pnbescens inhibit CaCl2-induced maximum contraction effect.Conclusion:Intestinal absorption solution of Angelica Pubescens shows vasodilator effects on a dose-dependent manner.The vasodilatation effect is mediated by inhibition of extracellular Ca2+ influx.
Keywords：Angelica PubescensIntestinal Absorption SolutionVasodilationMechanism
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 187-190,195 )