Over-relasing of β-endorphin Involves in the Formation of Both the Poor Appetite and Abdominal Distension in Spleen Qi Deficiency
WANG Ling-zhi
CHAI Ji-yan
LIU Xu-dong
LIU Wen-jun
ZHAO Jin-ru
WANG Shou-yan
SHAN De-hong
ZHANG Li-de
WANG De-shan
Abstract：Objective:To study the relation of β-endorphin (β-EP) in the formation of both the poor appetite and abdominal distension in spleen qi deficiency.Methods:20 male SD rats were randomly divided into the control and spleen qi deficiency group (model group),10 rats each group;metabolic cages were used to detect rat food and water intakes per day;carbon propulsion rate were applied to check the stomach residual rate and small intestine (SI) propelling rate (SIPR);ELISA and immohistochemistry were separately used to measure β-EP concentrations and μ receptor expressions in hypothalamic,stomach and SI tissues.Results:compared with those in the control,model rats significantly showed less food and water intake,reduced SIPR,and enhanced β-EP concentrations and μ receptor expressions of in the hypothalamic,stomach and SI tissues.Conclusion:the overrelease of β-EP involves in the formation of both the poor appetite and abdominal distension in spleen qi deficiency.
Keywords：Spleen qi deficiencyβ-EPPoor appetiteAbdominal distensionμ receptor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 184-186 )