Study on Phlegm Syndrome and Blood Stasis Syndrome in Coronary Artery Disease with Angina Pectoris Based on Metabolomics of Urine
ZHANG Hong-shuan
JIA Yu-hua
HUA He-yu
WAN Zhong-yuan
GUAN Shan-yue
CAO Shi-ping
CUI Kai
Abstract：Objective:To explore the urine metabonomic profile of angina pectoris patients with phlegm-turbid syndrome and blood-stasis syndrome.To examine potential application of metabonomic analysis in studies of Chinese Traditional Medicine syndromes of Angina Pectoris patients.Methods:Totally 12 cases of angina pectoris patients with phlegm-turbid syndrome (APPS),12 cases angina pectoris patients with blood-stasis syndrome (APBS) were enrolled in this study and their urine metabolites were analyzed using Hydro-Nuclear Magnetic Resonance (~1H NMR) spectrometer for the Partial Least Squares Discriminant Analysis (PLS-DA).Result:PLS-DA of urine ~1H-NMR spectra revealed different metabolic spectra between APPS patients and APBS patients,demonstrated that the metabolic characteristics of the two groups were significantly different.Compared with APPS patients,Citrate,α-ketoglutarate,Cis-aconitic acid,Glucose,3-Hydroxybutyrate,Acetone,Tyrosine,creatine,TMAO,Dimethylamine,Hippurate increased in APBS patients,while Bile acids,Histidine decreased considerably.Conclusion:Characteristic metabolic products in two groups can be identified by ~1H-NMR based metabonomics analysis.Metabonomic study is a feasible and promising way to detect the variation of urine etabonomics of Angina Pectoris patients with different TCM Syndromes.
Keywords：metabolomics~1H-NMRAngina Pectorissyndrome of TCM
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 126-128 )