Genes Transcription Characteristic in Neuroendocrine-immune Network About Typical Syndrome in Tumor-bearing Mice
FANG Zhao-qin
PAN Zhi-qiang
LU Wen-li
LIU Xiao-mei
GUAN Dong-yuan
LIANG Chao
GAO Bi-feng
Abstract：Objective:To study genes transcription general characteristics in neuroendocrine-immune network of tumor-bearing mice about poisonous pathogenic factors syndrome and asthenia of qi syndrome,asthenia of yang and qi syndrome, asthenia of qi and yin and yang syndrome. Methods : By analysis 60 GeneGhips data that were two batch experiments in 2006 and 2009. It has one million core genes, which involve hypothalamus and pituitary gland and adrenal gland and testiculus and thymus gland and spleen in normal contrast mice and four typical syndrome of H22 liver cancer mice. And genes consistent upregulated or consistent down-regulated are analyzed. Results:After the tumor, the consistent differences in gene expression of testiculus and thymus gland and spleen are in large quantities, followed by pituitary gland and adrenal gland, those characteristics are related to tumour disease. Gene expression of hypothalamus are more active about asthenia of qi syndrome tumor-bearing mice on earlier period.However,gene expression of adrenal gland are inhibit about poisonous pathogenic factors syndrome on earlier period,which may be related to the poor prognosis of pathogenic factors syndrome tumour mice.Conclusion : The biology characteristic substance can be exist about genes transcriptome in neuroendocrine-immune network of tumor-bearing mice about different syndrome with identical disease.
Keywords：tumoursyndromemiceGeneChipneuroendocrineimmunetranscriptome
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 33-37,27 )