Establishment of Animal Model with Chronic Fatigue Syndrome and Its Influence on Functions of Blood Vessel Endothelium
GAO Huai-lin
WU Yi-ling
ZHU Hui-ming
JIA Zhen-hua
LI Juan
YUAN Guo-qiang
WU Xiang-chun
WEI Cong
WANG Hong-tao
Abstract：Objective: To develop an animal model of the chronic fatigue syndrome (CFS) and to observe the change of the vascular endothelial function. Methods: The Wistar rats were randomly divided into two groups, the control and the fatigue group. The animal model of CFS was developed using a weight-loaded forced swimming test. Using this rat model, we investigated the change of the shape and function of vascular endothelium. Results: Behavior changes including the mental and physical fatigue were observed in the fatigued rats, which were similar to the clinical symptoms observed in the CFS patients. The damnification of the vascular endothelial cells in the fatigued rats was confirmed using light and electron microscopy. Moreover, The levels of the endothelin (ET) and the vascular yon Willebrand factor (VWF) were significantly increased (P < 0.01) whereas the level of NO was apparently decreased (P < 0.05). Conclusions: By employing the weight-loaded forced swimming test, we have developed a fatigued rat model, which was similar to the pathogenesis and symptoms of CFS. These results provided the experiment evidence for the prevention and cure of CFS and Karoshi.
Keywords：Chronic Fatigue SyndromeEndothelial functionAnimal model
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 904-906,919 )