Protective Role of Tongsai Granule on Phlegm-Heat Syndrome Model for Acute exacerbation of Chronic Obstructive Pulmonary Diseases in Rats
ZHOU Hong-yan
LI Jian-sheng
QIAO Cui-xia
ZHANG Yan-xia
Abstract：Objective: To study the protective mechanism of tongsai capsules in the AECOPD phlegm-heat model of rat. Methods: The AECOPD phlegm-heat model was established by smoking and dropping Klebsiella pneumoniae with stimulation of wind. the level of cytokine were tested by radioimmunology, Histopathological change of lung tissue and change of lung function were observed. Results: The contents of IL-8, TNF-α, CRP, ICAM-1 in tongsai group were less than those in model group. The VT,PEF were significantly increased, Ri were decreased. Conclusions: Decreasing the level of cytokine play a critical role in protective mechanism of promoting lung function and repairing pathological injury of tongsai capsules in the AECOPD phlegm-heat model of rat.
Keywords：chronic obstructive pulmonary diseasesphlegm-heat symptom of TCMcytokinelung function
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 756-758 )