Effect of Retarding Aging Chinese Drug Bushen Yijing Decoction on Rat Left-Ventricular Myosin Heavy Chain (MHC) mRNA Change with Aging
Abstract：Aim:To investigate the effect of BuShen Yi Jing decoction on rat left-ventricular myosin heavy chain(MHC)α and βgene expression change with aging. Methods:Wistar rats were randomly divided into three groups:untreated 8 and 24 months of aging,administration drug 24 months of aging. Rats were administration buShen Yi Jing decoction six months with 30 times adults human dose. Rats serum thyroxine(T4) and triiodothyronine(T3) levels using an radioimmunoassay(RIA) from clinic assay,RT-PCR method was used to evaluate α and βMHC mRNA expression. Results: T4 level was increased 1.24 times of senescent administration drug rats contrast to senility control rats (P<0.001)，αMHC mRNA enhanced 1.3 times (P<0.05) and β MHC mRNA decreased 74.32%(P<0.05). Conclusion: Bushen Yijing decoction had reversed effect on α and βMHC gene expression change with aging.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 34-36 )