Relationship between Changes of Coagulant and Fibrinolytic Activity of Monocyte in Coronary Heart Disease Patients and Different Syndrome-Type of TCM
LU Zhong
SHI Sai-zhu
ZHU Guang-li
Abstract：To study the relationship between changes of coagulant and fibrinolytic activity of human peripheral blood monocyte (PBMC) in coronary heart disease (CHD) patients and different syndrome-type of Traditional Chinese Medicine (TCM). Methods:80 patients with coronary heart disease were divided into three groups by syndrome differentiation. 30cases of blood stasis (BS), 27cases of phregm-damp(PD) and 23cases of Qi stagnation(QS). 20 healthy persons were enrolled as normal control group. Activity of tissue type plasminogen activator(t-PA) and its inhibitor (API-1) and procoagulant activity (PCA) of PBMC were measured by chromogenic substrate method respectively. Results: PAI-1 activity and PCA expression of PBMC in the CHD group were significantly higher while t-PA activity of PBMC was lower than those in the normal control group (P<0.01). PCA expression of PBMC in the BS group was significantly higher than that in PD and QS groups, PBMC t-PA expression in BS group was lower than that in PD and QS groups (P<0.01). No significant difference of PAI-1 activity of PBMC was found among BS、PD and QS groups (P>0.05). All param3eters were found no significant difference between PD and QS groups (P>0.05). Conclusions: There is a relationship between changes of coagulant and fibrinolytic activity of monocyte in coronary heart disease patients and different syndrome-type of TCM. The increasing level of PBMC PCA and reducing level of PBMC t-PA could be used as referential indices for differentiating BS and NBS(PD and QS). Patients of BS were in the notable prethrombotic state.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 59-61 )