Influence of “Yang Yin YiQiHuoXue Granules”on Norepinephrine During Jird Ischemia
Abstract：Objective: To investigate the effect of home-made“YangYinYiQiHuoXue Granules” on catecholamine levels in plasma of jird during brain ischemia. Methods: Experiments were performed on 60g～80g jird under chloral hydrate anesthesia. Brain ischemia induced by bilateral common carotid ligation for 30 min. A procedure with minimal plasma sample pretreatment, based on reversed-phase, ion-pair HPLC combined with electrochemical detection has been developed for the determination of the norepinephrine in plasma samples which divided into control, ischemia and fed on “YangYinYiQiHuoXue Granules” priors to ligation. Results: norepinephrine concentration increased markedly (P<0.05) in brain ishemia for 30min. While the ischemia animal fed on “YangYinYiQiHuoXue Granules” priors to ischemia 30min, comparing ischemia group, norepinephrine concentration decreased markedly (P<0.05). Conclusion: Ischemia induced by bilateral common carotid ligation leads to increment of plasma norepinephrine and “YangYinYiQiHuoXue Granules” can prevent this increasing.
Keywords：YangYinYiQiHuoXue GranulesischemiaHPLC-ECDnorepinephrine
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 22-24 )