Effect of Wen Shen HuoXue Chinese Drugs on Human Breast Carcinoma Cell Line MCF-7 Proliferation in Vivo and in Vitro
LIU Sheng
WU Xue-qing
LU De-ming
TANG Han-jun
Abstract：Results from the studying of breast cancer cell line MCF-7 in vivo and in vitro suggest the mechanism of suppressing cell proliferation of breast cancer by WEN SHEN HUO XUE Chinese drugs.Method:In vitro MTT method was used to detect the ability killing the tumor cells of serum with Chinese drugs.Cell cycle of breast cancer cell line MCF-7 which was treated by serum with Chinese drugs was detected by FCM.In vivo we have observed the effect of Chinese drugs on antitumor actions by nude mouse modal implanted MCF-7.Result:Serum concentration of 10%,20% and 30% WEN SHEN HUOXUE Chinese drugs could kill MCF-7 cells by 22.7%,33.1% and 37.4% respectively in vitro.(P<0.05) The growth suppression rate of MCF-7 of nude mice implanted tumor of WEN SHEN HUOXUE Chinese drugs could by up to 47.5%,44.2% and 51% respectively while the dose was 8g/kg,4g/kg and 2g/kg respectively.Conclusion:The study support the fact that WEN SHEN HUOXUE Chinese drugs can suppress proliferation of breast cancer by inhibiting DNA.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 54-57 )