Regulating Effects of Xinmaitong Capsule on Endothelin and Calcitonin Gene-related Peptide in Coronary Heart Disease Patients
Qiu Rui-Xing
HE Jing-bo
Abstract：to assess the protecting effect of Xinmaitong(XMT)capsule on myocardial ischemia. Methods:40 patients of coronary heart disease with myocardial ischemia were divided randomly into XMT group (20 cases) and control group (20 cases). Conventional western medical therapy was given to both groups and the XMT group received additional XMT treatment. The changes of endothelin (ET) and calcitonin gene-related peptide(CGRP) levels, ST segment of ECG and clinical symptoms after treatment in all the patients were observed. Data of 14 healthy persons were taken as normal control. Results:the ET level of all patients was significantly higher than that of normal control (P＜0.01),and level of CGRP in patients was not different from normal control significantly (P＞0.05).After treatment, results that:(1) The ET levels and the scores of clinical symptoms of both groups decreased significantly (P＜0.01), and ST segment elevated markedly (P＜0.01) as compared with before treatment, and the changes revealed more evident in XMT group in comparison with those of the control group (P＜0.05～0.01)；(2)The level of CGRP was significantly increased in XMT group (P＜0.01) while unchanged in the control group (P＞0.05).Conclusion:There is a regulating effect of XMT on regulatory polypetide. XMT could not only reduce significantly the plasma ET content, but also enhance markedly the production and release of CGRP, so it has a good ati-ischemic effect, which may be closely related with its action on improving the function of vascular endothelial cells and regulating metabolism of ET and CGRP.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 47-49 )