Experimental Study on Constitution of Erythrocyte Membrane and Change of Transmembrane Information Transmission in Male Rats of Kidney asthenia
Zheng hongxin
Cui Jiapeng
Liu Jingfeng
Lin Shuru
XIA Shujie
Abstract：The constitution and function of erythrocyte membrane and the changes of transmembrane information transmission in rats of kidney asthenia were investigated.In this study,a model of male rat of kidney asthenia was established by excision of sexual gland.The activities of protein kinase C (PKC),Ca2+-Mg2+-ATPase,Mg2+-ATPase in erythrocyte membrane and content of membrane phospholipid were observed.The results show that the activities of protein kinase C(PKC)and Ca2+-Mg2+-ATPase in erythrocyte membrane in the model group are significantly lower than those in the control group(P＜0.01).The contents of PC and PI in erythrocyte membrane are significantly lower(P＜0.01),that of PS is significantly lower (P＜0.05) and that of SM is significantly higher(P＜0.01).The kidney-tonifying traditional Chinese drugs can increase the activities of protein kinase C(PKC) and Ca2+-Mg2+-ATPase,decrease the content of SM(P＜0.01) and increase the content of PC,PI,PS(P＜0.01).It is concluded that the change of constitution and function of membrane in male rats of kidney asthenia can have effect on the asymmetry,fluidity and transmembrane information transmission.The kidney-tonifying traditional Chinese drugs can increase the activities of some of enzyme in membrane,correct some of constitution of membrane,such as SM,PC,PI,which can restore the constitution and function of membrane and the transmembrane information transmission,thus have the preventive and therapeutic effect on the diseases of kidney asthenia.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 25-27 )