Diagnosis,treatment and literature review of keratitis caused by Lasiodiplodia theobromae
YANG Dayou
YAN Zhiguang
SHI Defu
ZHANG Chunnuan
WU Chunli
LI Haini
CHEN Yaoyan
Abstract：Objective To study the diagnosis and treatment processes of keratitis caused by Lasiodiplodia theobromae and reviews the literature of the past 10 years.Methods Corneal scraping samples were collected from the affected areas of 2 keratitis patients admitted to our hospital.Two samples were respectively subjected to microscopy examination,fungal cul-ture,molecular biological examination,and the in-vitro antimierobial susceptibility of the isolated pathogen were performed.Results In both patients,the pathogens were identified as Lasiodiplodia theobromae.In-vitro antimierobial susceptibility tests showed that the pathogens were relatively sensitive to voriconazole and amphotericin B,with minimum inhibitory con-centrations(MICs)of 1 μg/mL and 2 μg/mL,respectively.And clinical use was effective.The previously published studies generally suggest that the affected sites of Lasiodiplodia theobromae were mainly the cornea and body surface.For body surface infections,voriconazole was the first-choice treatment,while for corneal infections,combined treatment with ampho-tericin B was required in addition to other therapies.Conclusions Keratitis caused by Lasiodiplodia theobromae is relatively rare in clinical practice,with great difficulties in diagnosis and treatment.Strain identification and in-vitro antimierobial sus-ceptibility tests may provide more precise medication guidance for clinical practice.
Keywords：fungal keratitisLasiodiplodia theobromaeclinical medication
Publication Date：2025-08-28
Online Publishing Date：2025-09-04(First online date of this platform, not the publication date of the document)
Pages：6( 393-398 )