Species distribution and drug resistance analysis of candidemia in children
ZHAO Mengchuan
ZHANG Wenchao
XING Jian
WANG Huiru
LI Mei
DUAN Suxia
ZHAI Yu
XU Qianru
WANG Dongxue
LI Yuanlong
GUO Yinghui
Abstract：Objective To investigate the species distribution and resistance profile of children's candidemia,and to provide evidence for prevention and reasonable diagnosis and treatment of candidiemia.Methods A retrospective analysis was carried out to analysis the clinical data of children with candidiemia hospitalized in Hebei Children's Hospital from January 2013 to December 2022.The demographic characteristics,species distribution,department source and antifungal drug sensitivity were analyzed.Results A total of 103 children with non-repetitive candidiemia were enrolled,including 70 males(67.96%)and 55 infants aged 29 days to 3 years(53.40%).Candida albicans(67 cases,65.05%)had the highest detection rate,followed by C.parapsilosis(16 cases,15.53%)and C.tropicalis(11 cases,10.68%).Over the last 10 years,the proportion of non-albicans Candida isolated in children with candidiemia showed an increasing trend,while the proportion of C.albicans showed a decreasing trend.The patients with candidemia were mainly from the surgery departmentsurgery department(47/103,45.63%),followed by the neonatology department(23/103,22.33%)and hematology department(13/103,12.62%).The susceptibility(wild type)rates of C.albicans,C.parapsilosis,C.tropicalis and C.glabrata to 5-fluorocytosine and amphotericin B were 100%.The sensitivity rates of C.parapsilosis and C.glabrata to azole antifungal drugs were 100%.The sensitivity of C.albicans to azole was higher than 92%.However,the resistance rates of C.tropicalis to fluconazole,itraconazole and voriconazole were 54.55%,36.36%and 45.45%,respectively.Conclusions Children with candidiemia usually occured in infants under 3 years of age,mainly caused by Candida albicans,and non-albicans Candida showing an increasing trend with time.5-fluorocytosine and amphotericin B could be used in the empirical treatment of candidiemia in our hospital.Azole antifungal drugs should be used with care for bloodstream infections caused by C.tropicalis.
Keywords：candidiemiachildrenspecies distributiondrug resistance
Publication Date：2025-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 34-38 )