Suboptimal voriconazole plasma concentration during cryptococcal treatment:a case report
LIAO Rongqiang
WANG Xiujuan
HE Yao
ZHENG Xiaoyuan
Abstract：Cryptococcal infection is mainly caused by Cryptococcus neoformans,which can attack human tissues such as lung and central nervous system.This paper presents a case of cryptococcal infection in a patient with a high probability of being a rapid metabolizer of CYP2C19,who experienced successive issues of fluconazole resistance and suboptimal voricon-azole plasma concentration during the course of anti-infective treatment.Timely adjustment to a combined therapeutic regi-men of amphotericin B liposome and flucytosine ultimately led to clinical improvement.This case analysis aims to provide valuable insights and reference for clinical practice.
Keywords：Cryptococcusdrug resistanceblood drug concentrationvoriconazoleCYP2C19 rapid metabolizer
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 285-287,305 )