Retrospective analysis of time to positive of 190 cases with candidiemia
JI Yueyue
GAO Shuo
ZHANG Yan
ZHOU Wanqing
Abstract：Objective To research the significance of time to positive of blood culture for early identification of candidemia.Methods A retrospective study of 190 samples of candidemia from Nanjing Drum Tower Hospital from January 2018 to March 2023 were applied to explore the role of TTP in C.tropical and C.glabrata.We used Student's t-test to analyse the TTP among different Candida species.The diagnostic values and cut-off values of the TTP for C.tropicalis and C.gla-brata were evaluated by the receiver operating characteristic(ROC)curve.Results The mean TTP of C.albican s(n=79),C.glabrata(n=26),C.parapsilosis(n=34)and C.tropicalis(n=37)(35.02±15.92)h,(56.70±24.92)h,(31.06±10.68)h,and(17.97±6.09)h respectively.The TTP of C.tropicalis shorter than other Candida species(P＜0.05).The TTP of C.glabrata longer than other Candida species(P＜0.0001).The area under the receiver operating characteristics(AUC)curve of C.tropicalis 0.9007 with a sensitivity of 94.59％,a specificity of 82.35％,a negative predictive value of 98.44％and a positive predictive value of 56.45％respectively,indicating TTP with a cut-off value of ≤23.76 h.The AUC curve of C.glabrata 0.8131 with a sensitivity of 61.54％and a specificity of 91.46％,a negative predictive value of 93.75％and a positive predictive value of 53.32％respectively,indicating TTP with a cut-off value of ≥46.27 h.Conclu-sions The TTP of C.tropicalis shorter than other Candida species.The TTP of C.glabrata longer than other Candida species.TTP be used for the early identification of C.tropicalis and C.glabrata in patients with candidemia.
Keywords：candidemiatime to positivityC.tropicalisC.glabrata
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 235-238 )