Analysis of common fungal infections and drug resistance
GONG Xiaoxue
MA Qian
YU Di
SHI Jiacheng
Abstract：Objective To analyze the types of fungal infections,distribution of clinical sample sources,and drug resistance in body fluid samples submitted by Shanghai Dian Medical Laboratory Co.,Ltd,in order to provide reference for the current status,influencing factors,treatment strategies,and development trends of fungal infections and drug resistance in the fu-ture.Method Collect 2681 clinical body fluid samples from January 2023 to July 2023 for cultivation,and analyze the bacte-rial distribution and drug sensitivity of 823 isolated fungi.Result The top five strains with the highest composition ratio were found to be Candida albicans(n=355),Candida glabrata(n=212),Candida tropicalis(n=105),Candida pa-rapsilosis(n=69),and Candida orthopsilosis(n=36).The composition ratio of Candida albicans is 43.1% ,accounting for nearly half of all isolated fungal specimens.Secondly,the composition ratio of Candida glabrata is 25.8% ,while the composition ratios of Candida tropicalis and Candida parapsilosis are 12.8% and 8.4% ,respectively.The top three types of body fluids in the composition ratio are urine(44.8% ),sputum(26.7% ),and blood(12.4% ).The sensitivity of 823 strains of fungi to 5-fluorocytosine,voriconazole,fluconazole,amphotericin-B,and itraconazole was tested,and these strains achieved a combined susceptibility to amphotericin-B of 98.5% ,and none of the strains were resistant to amphotericin-B,ex-cept for Trichosporon asahii.At the same time,the sensitivity of these strains to 5-fluorocytosine reached 97.3% ,and the sensitivity to voriconazole,fluconazole,and itraconazole was 92.8% ,63.1% ,and 62.3% ,respectively.Conclusion The main cause of infection is Candida spp.,which is mainly Candida albicans.These strains have good sensitivity to 5-fluoro-cytosine,while Candida tropicalis has a high resistance rate to fluconazole,voriconazole,and itraconazole,with a rate of o-ver 30% .
Keywords：fungihumoral infectionsdrug resistance analysis
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 138-142 )