The effect of andrographolide on the biofilm formation and adhesion ability of Fusarium keratoplasticum
PENG Yaqin
FANG Jingchun
WU Zhongwen
LIAO Kang
GUO Penghao
Abstract：Objective To investigate the effect of andrographolide on the biofilm formation and adhesion ability of Fusari-um keratoplasticum.Methods The crystal violet assay was performed to determine the effect of andrographolide on the bio-film formation and adhesion ability ofclinical multidrug-resistant Fusarium keratoplasticum.Results Compared with the blank control group,the 50% inhibitory effects on the adhesion of Fusarium keratoplasticum by andrographolide were ob-served at 64 μg/mL for 2 h-incubating time and 512 μg/mL for 4 h-incubating time,respectively.The Fusarium keratoplas-ticum strain had a strong biofilm-formation ability after incubating 24 h at 37℃.At the concentration of 2048 μg/mL,an-drographolide could inhibit 50% of the biofilm formation.Conclusions Andrographolide can inhibit the initial adhesion sig-nificantly and display certain activity against the biofilm formation of Fusarium keratoplasticum.
Keywords：andrographolideFusarium keratoplasticumbiofilmadhesion
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 113-116,137 )